摘要
戊型肝炎病毒(HEV)是导致全球急性病毒性肝炎的重要病因之一,且发病率有逐年上升趋势.部分特殊人群如孕妇、老年人、慢性肝脏疾病如慢性乙型肝炎和肝硬化等及免疫功能低下患者感染HEV后可导致急性、亚急性或慢加急性肝衰竭,病死率高.现从HEV感染的临床特点、HEV相关肝衰竭的发病机制以及诊治进展三个方面进行阐述,提升临床医师对HEV相关肝衰竭的识别和预防能力,改善其临床结局.
Abstract
Hepatitis E virus(HEV)is one of the important causes of acute viral hepatitis worldwide,and its incidence rate is increasing year by year.HEV infection can lead to acute,subacute,or acute-on-chronic liver failure with a high mortality rate among some particular patient population,who are pregnant women,older,chronic liver diseases like chronic hepatitis B and cirrhosis,or immunocompromised.The clinical characteristics of HEV infection,the pathogenesis of HEV-related liver failure,and the progress in diagnosis and treatment will be elaborated upon in this article from these three aspects in order to improve clinicians'ability to identify and prevent HEV-related liver failure and its clinical outcomes.
基金项目
国家自然科学基金地区项目(82060123)
贵州省科技厅基础项目(黔科合基础[2020]1Y299)
贵州省科技厅基础项目(黔科合基础-ZK[2021]重点013)
维普
万方数据