Chronic hepatitis B(CHB)is one of the major public health problems worldwide.The potential immunological mechanisms of hepatitis B virus(HBV)infection has not yet been clearly studied.Single-cell RNA sequencing(scRNA-seq)technology,as an emerging sequencing method in recent years,can provide a high-throughput view of the whole transcriptome at the single-cell level,reveal subtle changes in transcriptional profiles of immune cells during the course of chronic hepatitis B,and provide technological support for exploring the immunopathogenesis and potential therapeutic targets for CHB.This article summarizes the research progress conducted on scRNA-seq technology in order to provide novel therapeutic ideas for the immunological characteristics of chronic hepatitis B.
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