Objective:To investigate the epidemiological characteristics of polypoid lesions of the gallbladder (PLG) and influence factors of PLG progression.Methods:Clinical data of 627 PLG patients treated in the No.909 Hospital of Joint Logistic Support Forces of PLA from January 2019 to December 2020 were retrospectively analyzed. Among them, 343 patients were male and 284 female, aged from 21 to 70 years, with a median age of 42 years. 300 healthy subjects receiving physical examination in January 2020 were enrolled as healthy controls. The informed consents of all patients were obtained and the local ethical committee approval was received. The epidemiological characteristics of PLG patients were analyzed. Baseline data of PLG patients and healthy controls were compared. According to the follow-up results, PLG patients were divided into the progression and non-progression groups. The rates of two groups were compared by Chi-square test. The influence factors of PLG progression were identified by multivariate Logistic regression analysis.Results:Among 627 PLG patients, the proportion of patients aged30-40 years was the highest (38.4%), followed by 40-50 years (34.8%). The male-to-female ratio was 1.21∶1. The proportion of office staff was the highest up to 58.4%. The proportion of single PLG was 53.3%, slightly higher than 46.7% of multiple PLG. The proportion of PLG with a diameter of 1-6 mm was 63.3%. Non-wide basal PLG accounted for 88.4%. The proportion of diabetes mellitus, obesity, fatty liver and elevated blood lipids in PLG patients was significantly higher than that in healthy controls (χ2=13.646, 21.567, 17.758, 19.046; P<0.05). Multivariate analysis showed that wide basal PLG, elevated blood lipids, increased BMI and long-term staying up late were the independent risk factors for PLG progression (OR=2.366, 3.367, 4.124, 2.373; P<0.05).Conclusions:Wide basal PLG, elevated blood lipids, increased BMI and long-term staying up late are the risk factors for PLG progression.
万方数据
