Objective:To evaluate the safety and efficacy of laparoscopic partial splenectomy (LPS) in the treatment of benign space-occupying lesions in the spleen.Methods:Clinical data of 28 patients with benign space-occupying lesions in the spleen who underwent LPS in Shunde Hospital of Southern Medical University from June 2007 to September 2021 were retrospectively analyzed. The informed consents of all patients were obtained and the local ethical committee approval was received. Among them, 10 patients were male and 18 female, aged (40±17) years on average. All patients were divided into the LPS (n=15) and laparoscopic total splenectomy (LTS) groups (n=13) according to different surgical methods. In both LPS and LTS groups, all patients were mainly diagnosed with single lesion. In the LPS group, the lesions were mainly located in the upper and lower segments of the spleen, and primarily distributed in the hilum of the spleen in the LTS group. Perioperative conditions, and the impacts of surgical methods and postoperative time on the routine peripheral blood indexes were also observed between two groups. Routine peripheral blood indexes before and after surgery were compared by repeated-measures ANOVA.Results:All patients successfully completed the surgery without conversion to open surgery. No significant differences were noted in the operation time, intraoperative blood loss, proportion of intraoperative blood transfusion, time to first flatus, postoperative drainage time and length of postoperative hospital stay between two groups (P>0.05). In the LPS group, the postoperative 3-d and 3-month WBC was (9.0±2.7)×109/L and (6.0±1.9 )×109/L, significantly lower than (14.1±4.5)×109/L and (8.2±1.3)×109/L in the LTS group (t=-3.694, -3.488; P<0.05). Surgical method (t=-2.775, P<0.05) and postoperative time (F=53.182, P<0.05) were the main factors that affected WBC, and two factors exerted interactive effects (F=5.574, P<0.05). In the LPS group, the Plt was (236±92)×109/L at postoperative 3 months, significantly lower than (301±59)×109/L in the LTS group (t=-2.199, P<0.05). Postoperative time was the main influencing factor for Plt (F=10.490, P<0.05).Conclusions:LPS is a safe, feasible and effective surgical method for patients with benign space-occupying lesions in the spleen. LPS can preserve normal physiological function of the spleen to certain extent, promote the WBC and Plt to normal level, and may reduce the risk of postoperative infection and thrombosis.
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