Objective:To establish a ferroptosis-related long non-coding RNA (lncRNA) prognostic model for patients with intrahepatic cholangiocarcinoma (ICC) based on bioinformatics analysis.Methods:The gene expression data and clinical information of 36 patients with ICC and9 healthy counterparts were obtained from The Cancer Genome Atlas (TCGA) database, and the ferroptosis-related lncRNAs which were associated with clinical prognosis were extracted to establish the prognostic model. The predictive performance of ferroptosis-related lncRNA prognostic model was assessed by Cox's regression model and ROC curve. Survival analysis was carried out by Kaplan-Meier method andLog-rank test.Results:Multivariate Cox's regression analysis revealed that two ferroptosis-related lncRNAs, AL161431.1 and LINC01587, were the independent prognostic factors of ICC (HR=2.99, 7.23; P<0.05). The lncRNA prognostic model was established for patients with ICC. The risk score =1.096×AL161431.1+1.979×LINC01587. Significant difference was observed in the overall survival between high-risk and low-risk groups by Kaplan-Meier survival curve (χ2=6.54, P<0.05). Multivariate Cox's regression analysis demonstrated that the risk score of ferroptosis-related lncRNA was an independent prognostic factor (HR=1.12, P<0.05). The area under time-dependent ROC curve (AUC) of the 1-, 2- and 3-year survival of this model was 0.883, 0.837 and 0.853, respectively. However, 1-year survival AUC of time-dependent ROC curve of tumor grading and staging was 0.598 and 0.637. The prognostic prediction ability of this model was significantly better than those of tumor grading and staging.Conclusions:The prognostic model based on ferroptosis-related lncRNA can effectively predict the survival of patients with ICC.
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