Objective:To investigate the correlation between pathogenic bacteria of donor liver perfusion fluid and early infection of recipients after liver transplantation.Methods:Clinical data of 138 recipients who underwent orthotopic liver transplantation in Beijing Chaoyang Hospital, Capital Medical University from December 2019 to June 2022 were retrospectively analyzed. The informed consents of all patients or (and) their family members were obtained and the local ethical committee approval was received. Among them, 116 patients were male and 22 female, aged from 27 to 65 years, with a median age of 50 years.The results of donor liver perfusion culture and early infection of recipients after liver transplantation were analyzed.Results:Among 138 recipients of liver transplantation, the positive rate of pathogenic culture of donor liver perfusion was 51.4%(71/138), and 104 strains were isolated. The common pathogens included 45 strains of coagulase-negative Staphylococci, 9 strains of Enterococcus faecium and 7 strains of Escherichia coli. The incidence of recipient infection after liver transplantation was 28.3%(39/138), and 81 strains of pathogenic bacteria were isolated. The common pathogens included 13 strains of Klebsiella pneumoniae, 13 strains of coagulase-negative Staphylococcus and 7 strains of Escherichia coli. The incidence of postoperative infection was 39.4%(28/71) in the positive donor liver perfusion group, significantly higher than 16.4%(11/67) in the negative group (χ2=9.009, P<0.05). Among 28 recipients with postoperative infection in the positive group, identical pathogens were isolated in donor liver perfusion and postoperative infection culture of 9 recipients. Klebsiella pneumoniae was the most common pathogen, which was detected in donor liver perfusion culture of 6 cases and in postoperative infection culture of 5 cases, with a consistency rate of 5/6.Conclusions:The incidence of early infection after liver transplantation is high. The incidence of postoperative infection in recipients with positive results in donor liver perfusion pathogenic culture is higher than that in their counterparts with negative results. Klebsiella pneumoniae is a highly consistent pathogen between two culture tests.
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