Changes of serum α1-antitrypsin levels before and after hyperbaric oxygen treatment in patients with stable COPD and its clinical predictive value
Objective To explore the changes of serum α1-antitrypsin(α1-AT)levels before and after hyperbaric oxygen treatment in patients with stable COPD and its clinical predictive value.Methods A total of 59 patients with stable COPD admitted to the Department of Gerontology of the Affiliated Hospital of Putian University from August 2021 to July 2022 were selected as the research subjects.All patients received conventional symptomatic treatment after admission,and then the treatment combined with HBO therapy.Before and after treatment,serum α1-AT levels were measured by rate-scattering turbidity.Serum C-reactive protein(CRP)levels were measured by immunoturbidimetry,and the lung function changes were detected by pulmonary function meter.Spearman correlation analysis was used to analyze the relationship between serum α1-AT level,serum CRP level,and pulmonary function index.According to the prognosis,the patients were divided into good prognosis(n=34)group and poor prognosis group(n=25).Receiver operating charactecistic(ROC)curve was used to analyze the predictive value of serum α1-AT level after HBO therapy.Results The serum α1-AT level of 59 patients after treatment[(1.41±0.15)g/L]was significantly lower than that before treatment[(1.77±0.19)g/L],and the difference was statistically significant(t=11.423,P＜0.01).The serum CRP level after treatment[(3.52±0.75)mg/L)]was significantly lower than that before treatment[(7.75± 0.24)mg/L)],and the difference was statistically significant(t=41.261,P＜0.01).The Spearman correlation analysis showed that the serum α1-AT level was positively correlated with serum CRP level in 59 patients(r=0.874,P=0.034)and negatively correlated with pulmonary function index RV/TLC(r=-0.478,P=0.005).After treatment,serum α1-AT and CRP levels in the good prognosis group were significantly lower than those in the poor prognosis group(P＜0.05 or P＜0.01).The diagnostic specificity and sensitivity of serum α1-AT were significantly higher than those of CRP(79.3％vs.72.2％,and 82.4％vs.75.9％,all P＜0.05).Conclusion The serum α1-AT level in the patients with stable COPD was significantly decreased after HBO therapy,and the serum α1-AT level was low in the patients in the good prognosis group,which had good predictive value for prognosis.
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