Effects of hyperbaric oxygen therapy combined with early comprehensive rehabilitation nursing on neurological function and serum levels of IGF-1,IL-6,and neuron-specific enolase in children with hypoxic-ischemic encephalopathy
Objective To investigate the effects of hyperbaric oxygen therapy combined with early comprehensive rehabilitation nursing on the neurological function and serum levels of insulin-like growth factor-1(IGF-1),interleukin-6(IL-6),and neuron-specific enolase(NSE)in children with hypoxic-ischemic encephalopathy(HIE).Methods A total of 62 children with HIE admitted to the Neurosurgery Department of Linyi People's Hospital from February 2019 to February 2022 were selected as the study objects,and were divided into observation group and control group according to the random number table method,with 31 cases in each group.On the basis of hyperbaric oxygen therapy,the control group received conventional nursing,and the observation group received early comprehensive rehabilitation nursing.The main symptoms'recovery time,neonatal behavioral neurological assessment(NBNA)score,and serum levels of IGF-1,IL-6,and NSE before and after intervention were compared between the two groups.Results The consciousness recovery time,reflex recovery time,muscle tension recovery time,and sucking recovery time in the observation group were significantly shorter than those in the control group,and all the differences were statistically significant(P＜0.001).Before intervention,there was no statistically significant difference in NBNA scores and serum levels of IGF-1,IL-6,and NSE between two groups(P＞0.05).After intervention,the NBNA score and serum IGF-1 level in two groups were higher than those before intervention,and those in the observation group were higher than those in the control group,while the serum IL-6 and NSE levels were lower than those before intervention,and those in the observation group were lower than those in the control group,with statistically significant differences(P＜0.001).Conclusion Hyperbaric oxygen therapy combined with early comprehensive rehabilitation nursing can effectively improve the neurological function of children with HIE,increase the level of serum IGF-1,and reduce the levels of serum IL-6 and NSE.
Hyperbaric oxygenEarly comprehensive rehabilitation nursingHypoxic-ischemic encephalopathyChildrenInsulin-like growth factor-1Interleukin-6Neuron specific enolase
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