Clinical efficacy of Duhuo Jisheng Decoction combined with hyperbaric oxygen in the treatment of decompression osteonecrosis and its influence on hemorheology and coagulation function
Objective To explore the clinical efficacy of Duhuo Jisheng Decoction combined with hyperbaric oxygen in the treatment of patients with decompression osteonecrosis(DON)and its influence on hemorheology and coagulation function.Methods The clinical data of 23 patients with DON in Naval Medical Center of Naval Medical University and its coorperating unit from January 2022 to June 2023 were collected and divided into three groups according to their treatments:four cases in traditional Chinese medicine(TCM)decoction group(group A),11 cases in hyperbaric oxygen group(group B),and eight cases in TCM decoction+hyperbaric oxygen group(group C).The group A was treated with Duhuo Jisheng Decoction,the group B was treated with hyperbaric oxygen,and the group C was treated with Duhuo Jisheng Decoction combined with hyperbaric oxygen.The clinical efficacy was evaluated according to the Standards for Diagnosis and Curative Effect of Chinese Medical Symptom.Prothrombin time(PT),partial thromboplastin time(APTT),D-dimer(D-D),and fibrinogen(FBG)were measured by automatic coagulation analyzer.Whole blood viscosity(WBV)at high shear rate,whole blood viscosity(WBV)at low shear rate,and red blood cell aggregation index were measured by automatic hemorheological detector.Pain degree before and after treatment was evaluated by visual analogue scale(VAS).Activity of daily living(ADL)was used to evaluate the patients'living ability before and after treatment.Results The total effective rates of the group B(81.8%)and group C(87.5%)were significantly higher than that of the control group(25.0%),and the differences were statistically significant(P<0.01).After treatment,the ADL scores of the group B and group C were siginificantly higher than that of the group A,and the VAS scores were significantly lower than that of the group A(P<0.01).After treatment,the ADL score of the group C was significantly higher than that of the group B,and the VAS score of the group C was significantly lower than that of the group B(P<0.05).After treatment,whole blood viscosity(WBV)at low shear rate,whole blood viscosity(WBV)at high shear rate,and red blood cell aggregation index in the group C were significantly lower than those in the group A and group B(P<0.01).After treatment,D-D,FBG,PT,and APTT in the group C were significantly lower than those in the group A and group B(P<0.01).Conclusion The treatment of DON with Duhuo Jisheng Decoction combined with hyperbaric oxygen can improve the hemorheology of patients and regulate the coagulation function,therefore,obtaining better clinical efficacy.
Decompression osteonecrosisDuhuo Jisheng DecoctionHemorheologyCoagulation function