Efficacy of hyperbaric oxygen combined with donepezil in the treatment of Alzheimer's disease and its impact on the levels of serum humanin and endothelin-1
Objective To investigate the efficacy of hyperbaric oxygen combined with donepezil in the treatment of Alzheimer's disease(AD),and its effects on serum humanin and endothelin-1(ET-1).Methods A total of 98 patients with AD treated in Shanghai Mental Health Center of Shanghai Jiao Tong University School of Medicine from January 2021 to January 2024 were selected and randomly divided into a control group and an observation group according to the random number table method.The control group was treated with donepezil hydrochloride,while the observation group was treated with hyperbaric oxygen therapy on the basis of the treatment in the control group.Both groups were treated for 7 weeks.The scores of the cognition part of the AD assessment scale(ADAS-cog),the mini-mental state examination(MMSE),the Montreal cognitive assessment(MoCA),the neuropsychiatric inventory(NPI),the activities of daily living(ADL)before and after treatment,as well as the levels of serum humanin and ET-1,efficacy,and incidence of adverse reactions were compared.Results After treatment,the MMSE and MoCA scores of the observation group were higher than those of the control group,and the ADAS-cog score was lower than that of the control group,and the differences were all statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in NPI and ADL scores between the two groups of patients(P＞0.05).After treatment,the ADL score of the observation group was higher than that of the control group,and the NPI score was lower than that of the control group,and the differences were both statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in the levels of serum humanin and ET-1 between the two groups of patients(P＞0.05).After treatment,the serum humanin level of the observation group was higher than that of the control group,and the ET-1 level was lower than that of the control group,and the differences were both statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group and the control group were 12.24％(6/49)and 10.20％(5/49),respectively,and the difference was not statistically significant(P＞0.05).Conclusion The efficacy of hyperbaric oxygen combined with donepezil in the treatment of AD is better than that of donepezil alone,which can increase the serum humanin level,reduce the ET-1 level,improve the cognitive function and mental disorders of AD patients,and enhance patients'activities of daily living,and the treatment has relatively good safety.
Alzheimer's diseaseHyperbaric oxygenDonepezilHumaninEndothelinCognitive function
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