Effects and mechanism of hyperbaric oxygen combined with anisodine hydrobromide on optic disc blood flow density in patients with ischemic optic neuropathy
Objective To study the effects and mechanism of hyperbaric oxygen combined with anisodine hydrobromide on optic disc blood flow density in patients with ischemic optic neuropathy(ION).Methods A total of 90 patients with ION admitted to the Ophthalmology Department of Dongying People's Hospital from April 2020 to April 2023 were randomly divided into control group and study group using the random number table method,with 45 cases in each group.The control group was given anisodine hydrobromide injection,and the study group was given hyperbaric oxygen therapy on the basis of the treatment in the control group.The clinical efficacy was evaluated after two courses of treatment.The changes in mean sensitivity(MS),mean defect(MD),and loss variance(LV)of visual fields in the two groups before and after treatment were measured using an automatic perimeter.Visual acuity changes in both groups before and after treatment were assessed with the international standard logarithmic visual acuity chart.The blood flow density around and within the optic disc was measured by optical coherence tomography angiography(OCTA).The levels of serum endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)in the two groups were measured by enzyme-linked immunosorbent assay(ELISA).Results After treatment,the total effective rate in the study group(93.3％)was significantly higher than that in the control group(80.0％),and the difference was statistically significant(x2=5.075,P=0.024).After treatment,MS significantly increased,while the visual field parameters such as LV and MD levels significantly decreased in both groups(P＜0.01).Moreover,after treatment,the MS in the study group was higher than that in the control group,and LV and MD were significantly lower than those in the control group(P＜0.01).Compared with before treatment,visual acuity levels and blood flow density around and within the optic disc significantly increased in both groups after treatment,and they were significantly higher in the study group than those in the control group(P＜0.05).Compared with before treatment,the levels of serum VEGF and ET-1 decreased significantly in both groups,and they were significantly lower in the study group than those in the control group after treatment(P＜0.0 1).Conclusion Hyperbaric oxygen combined with anisodine hydrobromide can significantly improve the blood flow density of optic disc and the expression levels of vascular related factors in patients with ischemic optic neuropathy,promoting the recovery of visual field and visual function.
Ischemic optic neuropathyHyperbaric oxygenAnisodine hydrobromideOptic disc blood flow density
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