Observation of clinical efficacy of hyperbaric oxygen combined with oxcarbazepine in treating 52 pediatric patients with epilepsy secondary to viral encephalitis
Objective To investigate the clinical efficacy of hyperbaric oxygen combined with Oxcarbazepine on 52 pediatric patients with epilepsy secondary to viral encephalitis.Methods A total of 104 children with epilepsy secondary to viral encephalitis treated in the Department of Pediatrics of Hanzhong Central Hospital from June 2020 to June 2023 were selected as the study objects.According to the random number table method,those patients were divided into control group and observation group,with 52 cases in each group.The clinical efficacy of the two groups was compared after treatment,and the changes of neurological function before and after treatment were assessed by mini-mental state examination(MMSE).Before and after treatment,3 mL of fasting venous blood was taken and serum levels of interleukin(IL)-6,IL-8,tumor necrosis factor-α(TNF-α),vascular cell adhesion molecule-1(VCAM-1),and glial fibrillary acidic protein(GFAP)were detected by enzyme-linked immunosorbent assay.Results After treatment,the total effective rate of the observation group(96.15％)was significantly higher than that of the control group(80.77％),and the difference was statistically significant(x2=4.029,P=0.014).After treatment,MMSE scores of the two groups were significantly increased,and the MMSE score of the observation group was significantly higher than that of the control group(P＜0.01).After treatment,serum levels of IL-6,IL-8,TNF-α,VCAM-1,and GFAP in the two groups were significantly decreased,and the indexes of the observation group were all significantly lower than those of the control group(P＜0.01).Conclusion Hyperbaric oxygen combined with Oxcarbazepine in the treatment of epilepsy secondary to viral encephalitis can effectively inhibit vascular inflammation reactions and repair nerve function damage,thereby improving clinical efficacy.
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