Effects of hyperbaric oxygen combined with anti-heart failure treatment on cardiac function reserve and NT-proBNP expression in patients with dilated cardiomyopathy complicated with heart failure
Objective To investigate the effect of hyperbaric oxygen combined with anti-heart failure therapy on cardiac function reserve and N-terminal pro brain natriuretic peptide(NT-proNBP)expression in patients with dilated cardiomyopathy complicated with heart failure.Methods A total of 100 patients with dilated cardiomyopathy complicated with heart failure admitted to the Seventh People's Hospital of Zhengzhou from January 2022 to June 2024 were selected as the research subjects,who were randomly divided into observation group and control group using the random number table method,with 50 patients in each group.The control group patients were treated with benazepril and phentolamine,while the observation group received hyperbaric oxygen therapy in addition to the treatment of the control group.Echocardiography and phonocardiogram exercise tests were used to assess the cardiac reserve function[Cardiac contractility reserve index(CCRI),cardiac reserve index(CRI),6-minute walking distance].Pulmonary function tests were performed using a pulmonary function analyzer to measure the forced expiratory volume in one second(FEV1),FEV1/FVC(forced vital capacity),and peak expiratory flow rate(PEF).Enzyme linked immunosorbent assay was used to measure the serum NT-proBNP level.Hitachi 7600 fully automated biochemical analyzer was used to measure the serum cardiac troponin Ⅰ(cTnI)level,and immunoturbidimetry was used to measure the serum high-sensitivity C-reactive protein(hs-CRP)level.The clinical efficacy of two groups,as well as cardiac reserve function,pulmonary function,and serum NT-proBNP,cTnI,and hs-CRP expression levels before and after treatment,were compared.Results The total effective rate of treatment in the observation group(94.00％)was significantly higher than that in the control group(78.00％),and the difference was statistically significant(P＜0.05).Compared with before treatment,the cardiac reserve function of both groups increased after treatment,and those indexes in the observation group were higher than those in the control group(P＜0.05);the pulmonary function indexes all increased,and those indicators in the observation group were higher than those in the control group(P＜0.05);the levels of serum NT-proBNP,cTnI,and hs-CRP were all reduced,and those indexes in the observation group were lower than those in the control group(P＜0.05).Conclusion Hyperbaric oxygen combined with anti-heart failure therapy has a good therapeutic effect on patients with dilated cardiomyopathy complicated with heart failure,which can effectively improve the patient's cardiac reserve function and pulmonary function,regulate the levels of serum NT-proBNP,cTnI,and hs-CRP,and therefore it is worthy of clinical promotion and application.
Dilated cardiomyopathyHeart failureHyperbaric oxygenPulmonary functionCardiac function reserveN-terminal pro brain natriuretic peptide
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