Theranostics in nuclear medicine is an important direction for the precision medicine.Radionuclide therapy based on small molecules/peptides often requires high doses.Improving the utilization efficiency of radionuclides,optimizing the pharmacokinetics of radionuclide therapeutic molecular probes as well as increasing the target to non-target ratio have become the international hot frontiers in the field of ra-diotheranostics.Evans blue(EB)motif uses endogenous albumin as a reversible carrier,and the small mol-ecule and polypeptide structure modified based on EB can effectively extend the half-life in the blood and substantially increase the uptake,accumulation and retention of radiopharmaceuticals in target lesions,and thereby enhance the therapeutic effect and reduce the dosage of nuclides.This article focuses on the research of EB modified radiopharmaceuticals for theranostics.
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