Clinical investigation of Q.Flex for improvement of PET/CT image quality and quantitative accuracy of pulmonary nodules
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NETL
NSTL
万方数据
维普
目的 对比肺结节五维(5D)全息Q.Flex和常规三维(3D)PET/CT图像质量和代谢参数的差异,评估其临床实用价值.方法 回顾性收集2022年6月至2022年8月间于天津市肿瘤医院空港医院因可疑肺小结节而行PET/CT显像的54例患者[男30例,女24例;年龄60(42,75)岁;共78个18F-FDG高代谢实性肺结节(最大径≤3 cm)]的资料.所有患者接受5D PET扫描及3D、5D图像重建.比较5D和3D组间PET图像质量主观评分和信噪比(SNR),同时对比2组肺结节的定量参数:SUVmax、SUVmean和肿瘤代谢体积(MTV).组间差异采用x2检验、Wilcoxon符号秩检验比较,相关性分析采用Spearman秩相关分析.结果 5D组图像质量视觉评估≥4分的百分比和肺结节SNR 明显高于 3D 组,分别为 45％(35/78)和 28％(22/78)(x2=4.67,P=0.031)、37.46(18.42,62.00)和 32.72(16.97,54.76)(z=-4.07,P＜0.001);2 组间 SNR、SUVmax、SUVmean和 MTV 呈明显正相关(rs值:0.86、0.86、0.85和0.95,均P＜0.001);5D组SUVmax和SUVmean均明显高于3D组,分别为9.71(5.48,13.82)和 8.96(4.82,12.63)(z=-3.05,P＜0.001)、6.30(3.39,8.94)和 5.61(2.99,7.63)(z=-4.07,P＜0.001);而 5D 组 MTV 明显低于 3D 组,分别为 1.72(0.66,2.74)cm3 和 1.98(1.06,4.63)cm3(z=-7.13,P＜0.001).肺下野及最大径＞10 mm且≤20 mm的结节的5D定量参数较3D参数变化最明显(z值:-5.23～-2.48,均P＜0.05).结论 Q.Flex 5D PET明显改善肺结节SUV和代谢体积的定量准确度,且图像质量清晰,不增加辐射剂量,具有临床实用价值.
Objective To compare the imaging quality and metabolic quantitative parameters of pulmonary nodules between Q.Flex whole information five-dimensional(5D)and conventional three-dimen-sional(3D)PET/CT imaging for clinical evaluation.Methods Fifty-four patients(30 males,24 females,age:60(42,75)years;78 solid pulmonary nodules(maximum diameter≤ 3 cm)with abnormal uptake of 18F-FDG)from Tianjin Cancer Hospital Airport Hospital between June 2022 and August 2022 were enrolled in this retrospective study.All patients underwent 5D scanning and 3D,5D reconstruction.Image quality scores,signal-to-noise ratio(SNR),SUVmax,SUVmean and metabolic tumor volume(MTV)of pulmonary nodules of 5D group and 3D group were evaluated and compared with x2 test and Wilcoxon signed rank test.Correlation of quantitative parameters between 2 groups were analyzed by using Spearman rank correlation analy-sis.Results Thirty-five of 78(45％)pulmonary nodules with image quality score ≥4 were found in 5D group,which were more than those in 3D group(22/78(28％);x2=4.67,P=0.031).Meanwhile,SNR,SUVmax,SUVmean,and MTV were significantly positively correlated between the 2 groups(rs values:0.86,0.86,0.85,and 0.95,all P＜0.001).SNR,SUVmax and SUVmean of pulmonary nodules in 5D group were significantly higher than those in 3D group,which were 37.46(18.42,62.00)vs 32.72(16.97,54.76)(z=-4.07,P＜0.001),9.71(5.48,13.82)vs 8.96(4.82,12.63)(z=-3.05,P＜0.001)and 6.30(3.39,8.94)vs 5.61(2.99,7.63)(z=-4.07,P＜0.001)respectively.MTV of pulmonary nodules in 5D group was significantly lower than that in 3D group,which was 1.72(0.66,2.74)cm3 vs 1.98(1.06,4.63)cm3(z=-7.13,P＜0.001).Quantitative parameters of lower lung field and nodules with maximum diameters of＞10 mm and ≤20 mm based on 5D scanning changed most significantly compared with those based on 3D scanning(z values:from-5.23 to-2.48,all P＜0.05).Conclusion Q.Flex 5D PET significantly im-proves the quantitative accuracy of SUV and MTV of pulmonary nodules,and the improvement of image quality is substantial without increasing the radiation dose,which has clinical practical value.
NETL
NSTL
万方数据
维普
