Research progress of near-infrared Ⅱ fluorescence imaging in the diagnosis and treatment of tumors
Near-infrared(NIR)can be divided into MR-Ⅰ(650-900 nm)and MR-Ⅱ(900-1 700 nm)according to its wavelength.Compared with traditional NIR-Ⅰ fluorescence imaging,NIR-Ⅱ fluorescence imaging has lower tissue absorption and photon scattering as well as higher tissue penetration and resolution,which is considered as the most promising optical imaging technique in clinical application.In addition,combined with multimodal or therapeutic integrated molecular probes,NIR-Ⅱ fluorescence imaging can ac-curately localize tumors and guide treatment,providing a remarkable modality for early diagnosis and treat-ment of tumors.In this review,research progress on NIR-Ⅱ fluorescence imaging in the diagnosis,monito-ring of metastasis and treatment of tumors are mainly introduced.
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