FAPI核素显像在心血管疾病中的研究进展
Research progress of FAPI radionuclide imaging in cardiovascular diseases
韩佳莉 1李莉 1武萍 1宋建波 2李思进1
作者信息
- 1. 山西医科大学第一医院核医学科,太原 030001
- 2. 山西医科大学第三医院肿瘤中心,太原 030032
- 折叠
摘要
心肌纤维化是多种心血管疾病发生发展的重要病理过程,与患者预后密切相关.活化的成纤维细胞(CFs)是其中主要的效应细胞,其表面特异性高表达成纤维细胞激活蛋白(FAP).核素标记的FAP抑制剂(FAPIs)能与FAP特异性结合,在体可视化活化的CFs,在多种心血管疾病的早期诊断、预后预测及干预指导中表现出初步的临床应用价值.该文就核素标记的FAPIs在心血管疾病显像中的研究进展进行综述.
Abstract
Myocardial fibrosis is an important pathological process in the development of cardiovas-cular diseases,which is closely related to the prognosis of patients.Activated cardiac fibroblasts(CFs)are the main effector cells,whose surface specifically overexpress fibroblast activation protein(FAP).Radionu-clide-labeled FAP inhibitors(FAPIs)can specifically bind to FAP to visualize activated CFs in vivo,show-ing preliminary clinical application in the early diagnosis,prognosis prediction and interventional guidance of various cardiovascular diseases.This article reviews the progress of researches on the application of radio-nuclide-labeled FAPIs in cardiovascular diseases imaging.
关键词
心血管疾病/拮抗剂和抑制剂/膜蛋白质类/成纤维细胞/发展趋势Key words
Cardiovascular diseases/Antagonists and inhibitors/Membrane proteins/Fibroblasts/Trends引用本文复制引用
出版年
2024
NETL
NSTL
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