Research progress of FAPI radionuclide imaging in cardiovascular diseases
Myocardial fibrosis is an important pathological process in the development of cardiovas-cular diseases,which is closely related to the prognosis of patients.Activated cardiac fibroblasts(CFs)are the main effector cells,whose surface specifically overexpress fibroblast activation protein(FAP).Radionu-clide-labeled FAP inhibitors(FAPIs)can specifically bind to FAP to visualize activated CFs in vivo,show-ing preliminary clinical application in the early diagnosis,prognosis prediction and interventional guidance of various cardiovascular diseases.This article reviews the progress of researches on the application of radio-nuclide-labeled FAPIs in cardiovascular diseases imaging.
Cardiovascular diseasesAntagonists and inhibitorsMembrane proteinsFibroblastsTrends
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