Dual-tracer PET imaging can provide more comprehensive clinical information for dis-ease diagnosis.How to achieve dual-tracer imaging through single imaging session is one of the hot topics in the field of nuclear medicine.The key issues in achieving dual-tracer imaging with a single scan is the accu-rate separation of single-tracer information from the mixed tracer signal.In the last two decades,separation methods for different tracers have been proposed,and the injection interval between two tracers was reduced.This paper summarizes recent dual-tracer separation methods.The basic principles,features and advantages of separation methods are analyzed.Besides,the outlook on the future development of dual-tracer separation is also discussed in the present review.
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