Oral and maxillofacial malignant tumors threaten the life and health of patients,and seri-ously affect their swallowing,language function and face.125I seeds brachytherapy for oral and maxillofacial malignant tumors has been widely concerned and studied because of its advantages such as less surgical trauma,large and uniform dose distribution in the target tissue,little damage to the surrounding normal tissue,and reducing radiation exposure of medical staff.Low-dose brachytherapy with 125I seeds can effectively reduce the tumor volume and prolong the survival time of patients.This article reviews the clinical application of 125I seeds brachytherapy in oral and maxillofacial malignant tumors.