Application value of 18F-D3FSP PET/CT in patients with cognitive impairment of varying degrees
Objective To explore the effectiveness of18F-deuterated-Florbetapir(D3FSP)PET/CT imaging in detecting β-amyloid(Aβ)deposition in the brain and its correlation with plasma biomarkers.Methods A retrospective analysis was conducted on 79 patients(32 males,47 females;age(66±7)years)who underwent 18F-D3FSP PET/CT imaging from June 2022 to November 2023 at the First Affiliated Hospital,Guangzhou Medical University,as a part of the Greater Bay Area Healthy Aging Brain Longitudi-nal Cohort Study(GHABS).Based on the Alzheimer's Disease Neuroimaging Initiative cohort standard pro-tocol,patients were categorized into cognitively unimpaired(CU)group,mild cognitive impairment(MCI)group,and Alzheimer's disease(AD)group.Brain regions were segmented using the AW workstation and the SUV ratio(SUVR)was calculated with the cerebellum as the reference region.One-way analysis of vari-ance,Bonferroni correction and Pearson correlation analysis were used to analyze data.The ROC curve anal-ysis was used to analyze the cut-off value and the diagnostic efficacy of SUVR.Results There were 48,15 and 16 cases in CU,MCI and AD groups respectively.During the transition from CU to MCI and then to AD,there was a rising trend in SUVR(F values:11.15-22.38,all P＜0.001)across the whole brain and various brain regions(bilateral frontal lobes,bilateral anterior cingulate gyrus,bilateral precuneus,bilater-al parietal lobes,bilateral lateral temporal lobes,and bilateral occipital lobes).SUVRs of the right anterior cingulate gyrus and bilateral precuneus were different between the CU and MCI groups(all P＜0.017),and those of bilateral frontal lobes,right precuneus,bilateral parietal lobes,bilateral lateral temporal lobes,and bilateral occipital lobes were different between the MCI and AD groups(all P＜0.017).SUVRs of brain re-gions were negatively correlated with cognitive scale scores(r values:from-0.57 to-0.37,all P＜0.001),and were positively correlated with plasma phosphorylated tau181(p-tau181,r values:0.50-0.61,all P＜0.001).The ROC curve analysis suggested that the cut-off value of SUVR in the precuneus for distinguis-hing CU from AD was 1.20,with the AUC,sensitivity,specificity and accuracy of 0.85,12/16,91.7％(44/48)and 87.5％(56/64),respectively.Conclusion 18F-D3FSP PET/CT imaging has good clinical ap-plication value in assessing the deposition sites and the extent of Aβ in the brain,which is related to clinical cognition and plasma p-tau181 level.
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