PSMA PET在分化型甲状腺癌中的临床应用进展
Clinical application progress of PSMA PET in differentiated thyroid cancer
张恩碧 1张万春2
作者信息
- 1. 山西医科大学医学影像学院,太原 030001
- 2. 山西白求恩医院核医学科,太原 030032
- 折叠
摘要
分化型甲状腺癌(DTC)是常见的内分泌肿瘤之一.绝大多数的DTC预后较好,部分中高危DTC患者可能在自然病程或治疗过程中出现摄碘能力下降,或虽然保持摄碘能力但仍出现病情进展.18F-FDG PET/CT对探测此类患者的复发或转移病灶有较高的提示意义,但也会有假阴性的可能.肿瘤新生血管在肿瘤转移、侵袭的过程中发挥重要作用.前列腺特异膜抗原(PSMA)在DTC新生血管中也有表达,提示PSMA PET在甲状腺癌中具有潜在价值.该文对PSMA PET在DTC中的临床应用进展进行综述.
Abstract
Differentiated thyroid cancer(DTC)is one of the common endocrine tumors,and the vast majority of DTC have a good prognosis.Some medium-and high-risk patients with DTC may have de-creased iodine uptake or progression in spite of maintaining iodine uptake in the natural course of disease or during treatment.18F-FDG PET/CT is of high significance in detecting recurrent or metastatic lesions in such patients,but there is also a possibility of false negative result.Tumor neovascularization plays an im-portant role in the process of tumor metastasis and invasion.Prostate specific membrane antigen(PSMA)is also expressed in DTC neovascularization,suggesting that PSMA PET has potential value in thyroid cancer.This article reviews the clinical application progress of PSMA PET in DTC.
关键词
甲状腺肿瘤/前列腺特异膜抗原/正电子发射断层显像术/发展趋势Key words
Thyroid neoplasms/Prostate-specific membrane antigen/Positron-emission tomo-graphy/Trends引用本文复制引用
出版年
2024
NETL
NSTL
万方数据