Differentiated thyroid cancer(DTC)is one of the common endocrine tumors,and the vast majority of DTC have a good prognosis.Some medium-and high-risk patients with DTC may have de-creased iodine uptake or progression in spite of maintaining iodine uptake in the natural course of disease or during treatment.18F-FDG PET/CT is of high significance in detecting recurrent or metastatic lesions in such patients,but there is also a possibility of false negative result.Tumor neovascularization plays an im-portant role in the process of tumor metastasis and invasion.Prostate specific membrane antigen(PSMA)is also expressed in DTC neovascularization,suggesting that PSMA PET has potential value in thyroid cancer.This article reviews the clinical application progress of PSMA PET in DTC.
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