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重视老年肺炎治疗的优化

Optimal strategies for the treatment of senile pneumonia

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老年肺炎治疗难度大,病死率较高.新近发表的《老年肺炎临床诊断与治疗专家共识(2024年版)》指出,初始经验性抗感染治疗应当覆盖老年肺炎常见的病原体,并兼顾患者脏器功能和合并用药等因素,同时需要重视抗感染药物以外的综合治疗.本文围绕该共识,就如何制定初始治疗方案,准确评估治疗效果、调整治疗方案,及抗感染治疗以外的综合治疗措施等展开评述.
China has become an ageing society.Senile pneumonia is on the rise and is characterized by an insidious onset and rapid progression.Senile pneumonia is difficult to treat and has a high mortality.Therefore,the Respiratory Committee of Chinese Geriatrics Society has launched the"Chinese expert consensus on the diagnosis and treatment of senile pneumonia(2024 Edition)".The"consensus"has proposed the following treatment principles.As soon as possible the diagnosis is made,the appropriate empirical antimicrobial therapy should be started.Antimicrobials that are safe and have fewer drug-drug interactions should be preferred on the premise of efficacy.After 48 to 72 hours of initial treatment,clinical efficacy should be assessed and antimicrobial therapy should be optimized.Initial empirical antimicrobial therapy should cover the most common pathogens.The pathogen spectrum in senile pneumonia is different from that in younger patients.The initial empirical antimicrobial therapy should be based on the patient's underlying diseases,the risk of multidrug-resistant(MDR)bacteria and the severity of pneumonia.Individualized therapy is important for senile pneumonia.Therapeutic effect should be evaluated 48-72 hours after the initial therapy,including clinical manifestations and laboratory tests.At the same time,the patient's cognition,diet,sleep,and organ function should also be evaluated.If the initial treatment fails,the reasons should be quickly identified,and the treatment should be adjusted accordingly.In addition to anti-infective therapy,a comprehensive approach should be considered,including support of organ function,cautious use of glucocorticoids,sputum drainage,early and appropriate rehydration and nutritional support.

苏欣、贺彬婵

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南京大学医学院附属鼓楼医院呼吸与危重症医学科,南京 210008

南京中医药大学第二附属医院呼吸与危重症医学科,南京 210017

2025

中华结核和呼吸杂志
中华医学会

中华结核和呼吸杂志

北大核心
影响因子:2.692
ISSN:1001-0939
年,卷(期):2025.48(1)