Objectives To investigate the safety and efficacy of laparoscopic-assisted subtotal colectomy in the treatment of synchronous multiple primary colorectal cancer(sMPCC)with distant intervals or spanning more than one colon segment.Methods This was a retrospective analysis of 27 patients with synchronous multiple primary colorectal cancer receiving laparoscopic surgery at Department of Gastrointestinal Surgery,Affiliated Hospital of Jiangnan University,between January 2013 and June 2021.Patients were divided into treatment group(n=16,receiving laparoscopic-assisted subtotal colectomy)and control group(n=11,receiving laparoscopic-assisted segmented radical resection of colorectal cancer).The operation data and postoperative curative effect were recorded.Results Surgeries were uneventful in 27 cases without conversion to laparotomy,and there were no serious complications after operation in both groups.There was no significant difference between the two groups in duration of surgery(t=-0.154,P＞0.05),intraoperative blood loss(Z=-0.919,P=0.358),time to intestinal function recovery(t=-1.268,P＞0.05),and incidence of surgery-related complications.The frequency of defecation 6 months after operation in the observation group was higher than that in the control group,and the difference was statistically significant(t=4.159,P=0.000).The number of lymph node dissection in treatment group was higher than that in the control group(t=3.202,P＜0.01).The operation cost in the treatment group was less than that in the control group(t=-3.811,P＜0.01),and the difference was statistically significant.No anastomotic recurrence occurred in the two groups at the follow-up of 12～24 months,and the bowel movements were in good condition.Conclusion Laparoscopic-assisted subtotal colectomy is safe and effective in treating trans-segment synchronous multiple primary colorectal cancer,its short-term outcome is satisfactory,the procedure has demonstrated benefits in lymph node dissection and reduced operation cost.
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