腭部发育分子机制的研究进展
Research progress in molecular mechanism of palatal development
王斌卿 1宋涛1
作者信息
- 1. 中国医学科学院北京协和医学院整形外科医院唇腭裂中心,北京 100144
- 折叠
摘要
腭裂是常见的颌面部出生缺陷之一,可单独发生,也可与多种畸形伴发于综合征.腭突需要在胚胎发育特定时间窗内完成垂直向生长、抬高、黏附和融合等过程,此过程中任一阶段出现异常均可能导致腭裂.既往研究已明确多个参与腭突生长、定位、融合的分子调控网络,近年来对于腭部发育的分子学研究不断深入,但对于腭部发育调控机制仍存在很多未知,腭裂的发病机制仍未被阐明.本文总结近年腭突增殖、抬高定位、黏附和融合的主要研究进展,并结合基因、分子途径和细胞、形态发生过程进行综述,以较全面地了解基因型-表型功能关系,为制订腭裂疾病的有效预防策略提供帮助.
Abstract
Cleft palate is one of the most common maxillofacial birth defects,which can occur alone or accompany with many known deformities.Palatal selves need to complete the process of vertical growth,elevation,adhesion and fusion in a specific time window of embryo development.Any abnormality in this process will lead to cleft palate.Although previous studies have identified many molecular networks that regulate the growth,location and fusion of palatal selves,there are still many unknown mechanisms for palatal development.The pathogenesis of cleft palate has not been clarified so far.In recent years,the molecular research on palate development has been deepened continuously.Here we summarize major recent advances and integrate the genes and molecular pathways with the cellular and morphogenetic processes of palatal shelf growth,patterning,elevation,adhesion,and fusion,in order to comprehensively understand the genotype-phenotype functional relationship and provide assistance in formulating effective prevention strategies for cleft palate disease.
关键词
腭/腭裂/胚胎发育/分子机制/转录因子/信号通路Key words
Palate/Cleft palate/Embryonic development/Molecular mechanism/Transcription factors/Cell signaling引用本文复制引用
基金项目
中国医科院医学与健康科技创新工程项目(2021-I2M-1-052)
出版年
2024
NETL
NSTL
维普
万方数据