Progress and prospects of liquid-liquid phase separation in developmental diseases
Membrane-bound organelles as well as membrane-free compartments exist in eukaryotic cells,which divide the nucleus and cytoplasm into distinct subregions and allow specific biochemical reactions to occur.The physiological mechanisms of membrane-bound organelles have been extensively characterized,but the formation and function of membrane-free compartments have not been thoroughly studied.Over the past decade,significant progress had been made in the studies about the role of liquid-liquid phase separation(LLPS)in the formation of membrane-free organelles.LLPS which serves as an aggregated separation mechanism for cellular biochemical reactions,is associated with a variety of physiological processes such as signal transduction and gene transcriptional regulation;while aberrant LLPS may contribute to the occurrence of developmental diseases.The present review investigates the role of LLPS as a mechanism of aggregation and segregation of cellular biochemical responses.The mechanisms of LLPS development and recent advances in the relationships between aberrant LLPS and developmental diseases are forward discussed,as well as how these advances may aid in the development of LLPS-based therapies.
Cell compartmentationLiquid-liquid separationDevelopmental diseasesMembraneless organellesIntrinsically disordered regions
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