颞下颌关节骨关节炎（TMJOA）是颞下颌关节退行性疾病，发病率高，严重影响患者生活质量，但其发病机制不明。研究发现血管生成参与TMJOA的进展并与关节软骨基质降解、软骨下骨硬化、骨赘形成，疼痛等密切相关。本文综述近年来TMJOA中血管生成研究相关进展，并为TMJOA的治疗提供展望。 Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease of temporomandibular joint, which has a high incidence and affects the quality of patients′ life. While the pathogenesis of TMJOA remains unclear. It has been found that angiogenesis is involved in the development of TMJOA and it is closely related to the degradation of articular cartilage matrix, subchondral ossification, osteophyte formation and pain. This article reviews the recent advances in the study of angiogenesis in TMJOA, and provides a prospect for the treatment of TMJOA.
Recent research advances of angiogenesis in temporomandibular joint osteoarthritis
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease of temporomandibular joint, which has a high incidence and affects the quality of patients′ life. While the pathogenesis of TMJOA remains unclear. It has been found that angiogenesis is involved in the development of TMJOA and it is closely related to the degradation of articular cartilage matrix, subchondral ossification, osteophyte formation and pain. This article reviews the recent advances in the study of angiogenesis in TMJOA, and provides a prospect for the treatment of TMJOA.
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