口腔鳞状细胞癌（OSCC）是口腔癌的主要类型，其发病率高，侵袭能力强，易转移，疗效不佳，预后较差，给患者的口颌正常功能、外形、人际交往和心理状态造成巨大负面影响。固有淋巴样细胞（ILC）是驻扎在黏膜屏障中的重要免疫细胞组分，在肿瘤发生、发展、转归等进程中均发挥重要作用，是解码肿瘤微环境调控机制、全景式绘制肿瘤进展的关键细胞。本文简要综述ILC的研究进展，归纳ILC在OSCC免疫微环境中可能的特性及作用，挖掘ILC和OSCC发生、发展的关联，为OSCC免疫治疗提供新的思路。 Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. It has a high incidence, strong invasion ability, easy metastasis, poor curative effect, and poor prognosis. Innate lymphoid cells (ILCs) are an important part of immune cells located in the mucosal barrier, which play an important role in the occurrence, development and outcome of tumors. ILCs are the key cells for decoding the regulatory mechanism of tumor microenvironment and the signatures for tumor progression. This paper reviewed the latest progress on ILCs, summarized the possible characteristics and functions of ILCs in the microenvironment of OSCC, and explored the relationship between ILCs and the occurrence, development and immunotherapy of OSCC.
Abstract
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. It has a high incidence, strong invasion ability, easy metastasis, poor curative effect, and poor prognosis. Innate lymphoid cells (ILCs) are an important part of immune cells located in the mucosal barrier, which play an important role in the occurrence, development and outcome of tumors. ILCs are the key cells for decoding the regulatory mechanism of tumor microenvironment and the signatures for tumor progression. This paper reviewed the latest progress on ILCs, summarized the possible characteristics and functions of ILCs in the microenvironment of OSCC, and explored the relationship between ILCs and the occurrence, development and immunotherapy of OSCC.
关键词
癌,鳞状细胞/固有淋巴样细胞/肿瘤微环境/杀伤细胞,天然/肿瘤发生/肿瘤进展
Key words
Carcinoma, squamous cell/Innate lymphoid cell/Tumor microenvironment/Killer cells, natural/Tumor progression/Tumor development
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