固有淋巴样细胞在口腔鳞状细胞癌微环境中的作用探讨

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中文摘要：口腔鳞状细胞癌（OSCC）是口腔癌的主要类型，其发病率高，侵袭能力强，易转移，疗效不佳，预后较差，给患者的口颌正常功能、外形、人际交往和心理状态造成巨大负面影响。固有淋巴样细胞（ILC）是驻扎在黏膜屏障中的重要免疫细胞组分，在肿瘤发生、发展、转归等进程中均发挥重要作用，是解码肿瘤微环境调控机制、全景式绘制肿瘤进展的关键细胞。本文简要综述ILC的研究进展，归纳ILC在OSCC免疫微环境中可能的特性及作用，挖掘ILC和OSCC发生、发展的关联，为OSCC免疫治疗提供新的思路。 Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. It has a high incidence, strong invasion ability, easy metastasis, poor curative effect, and poor prognosis. Innate lymphoid cells (ILCs) are an important part of immune cells located in the mucosal barrier, which play an important role in the occurrence, development and outcome of tumors. ILCs are the key cells for decoding the regulatory mechanism of tumor microenvironment and the signatures for tumor progression. This paper reviewed the latest progress on ILCs, summarized the possible characteristics and functions of ILCs in the microenvironment of OSCC, and explored the relationship between ILCs and the occurrence, development and immunotherapy of OSCC.

外文标题：Role of innate lymphoid cells in oral squamous cell carcinoma microenvironment

外文摘要：Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. It has a high incidence, strong invasion ability, easy metastasis, poor curative effect, and poor prognosis. Innate lymphoid cells (ILCs) are an important part of immune cells located in the mucosal barrier, which play an important role in the occurrence, development and outcome of tumors. ILCs are the key cells for decoding the regulatory mechanism of tumor microenvironment and the signatures for tumor progression. This paper reviewed the latest progress on ILCs, summarized the possible characteristics and functions of ILCs in the microenvironment of OSCC, and explored the relationship between ILCs and the occurrence, development and immunotherapy of OSCC.

外文关键词：

Carcinoma, squamous cellInnate lymphoid cellTumor microenvironmentKiller cells, naturalTumor progressionTumor development

作者：

刘丽萍、查月、王瑾瑜、徐恋祎、秦旭、陈素红

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作者单位：

华中科技大学同济医学院口腔医学院，武汉　430030

华中科技大学同济医学院附属同济医院口腔医学中心　华中科技大学同济医学院口腔医学院　口腔颌面发育与再生湖北省重点实验室，武汉　430030

关键词：

癌,鳞状细胞固有淋巴样细胞肿瘤微环境杀伤细胞,天然肿瘤发生肿瘤进展

基金：

国家自然科学基金宁夏回族自治区重点研发计划湖北省自然科学基金华中科技大学大学生创新创业项目华中科技大学教学研究项目

项目编号：

818009812022BEG031602023AFB765S2022104873582021158

出版年：

2024

DOI：

10.3760/cma.j.cn112144-20240129-00041

中华口腔医学杂志

中华医学会

中华口腔医学杂志

CSTPCD北大核心

影响因子：1.194

ISSN：1002-0098

年,卷(期)：2024.59(4)

参考文献量49