The orofacial system,an intricate assembly of diverse tissues that underpin the unique biologic and morphological identity of an individual,presents a formidable challenge in the realm of tissue regeneration within oral and maxillofacial surgery.This review conducts a retrospective appraisal of advancements in the field of orofacial tissue regeneration,elucidating the current research landscape while critically addressing the persisting challenges.It underscores the pivotal roles of orofacial mesenchymal stem cells in orchestrating regenerative processes,offering an insightful outlook on future developments.The objective is to demarcate innovative therapeutic avenues and clinical implications by fostering a comprehensive understanding of this domain among dental practitioners.As such,it aspires to serve as a valuable reference for prospective investigations and to elevate the knowledge base pertaining to orofacial tissue regeneration.
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