Congenital infiltrating lipomatosis of face (CILF) is a rare disease that is congenital, non-hereditary, and increased infiltrating adipose tissue. CILF is mostly found at birth, with the main clinical manifestations of obvious facial soft tissue swelling, jaw bone swelling, early eruption of permanent teeth, macrodontism, etc. It is often occurring to the lower 2/3 parts of the face, and the left side. Imaging examination shows fatty infiltration of soft tissues in the affected face. This article reported two cases of CILF, and reviewed its etiology, clinical manifestations, diagnosis, and treatment progress.