摘要
机械敏感离子通道（MS离子通道）是一类能感知机械应力的重要蛋白，将细胞外机械刺激信号转化为电化学信号，导致离子跨膜流通，继而传递至胞内调控下游靶基因。牙源性细胞胞膜表面有多种MS离子通道表达，但其如何调控细胞功能和具体机制仍不明确。本文就MS离子通道的分类及其在牙源性细胞的表达和功能作一综述。
Abstract
As crucial proteins in sensing mechanical stress, mechanosensitive (MS) ion channels could transform external mechanical stimuli into electrochemical signals, enabling ion transmembrane movement. This movement signals the intracellular regulation of target genes. While various MS ion channels are present in odontogenic cell membranes, their roles in the cellular regulation and the exact mechanisms are still not fully understood. This review focused on the classification, expression, and functionality of MS ion channels in odontogenic cells.
基金项目
广东省自然科学基金(2021A1515010845)
广东省医学科学技术研究基金(A2022126)
万方数据