Digitalization and information technology have been the main theme of Oral Medicine since the 21st century. In particular, the application of artificial intelligence technology in Prosthodontics can promote the intelligent upgrading of the entire process from the initial diagnosis to the follow-ups after treatment. This article introduced the concept of the current artificial intelligence technologies, discussed the application and progress of artificial intelligence in Prosthodontics, as well as the existing deficiencies at the current stage and the future development directions, so as to provide references for clinical dentists and scientific researchers to further integrate Oral Medicine with artificial intelligence.