Platelet rich plasma for treatment of knee osteoarthritis: current status and prospect
As an important non-operative treatment, new biological agents represented by platelet rich plasma have achieved specific results in the treatment of knee osteoarthritis and received great attention. However, at present, the application of platelet rich plasma in knee osteoarthritis lacks high level research, the preparation, usage, and indication selection lack unified standards, and the mechanism of action on articular cartilage is not completely clear, which has caused some controversy on the clinical application of platelet rich plasma. Based on the existing research, this article will describe the current situation of platelet rich plasma from six aspects: mechanism of action, indication selection, preparation, optimal use, perioperative management, and clinical efficacy, and discuss its future development.
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