Clinical significance of serum S100β, ischemic-modified albumin, and heat-shock protein 70 in cognitive impairment of patients with cerebral small vascular disease
Objective:To investigate the expression of serum S100 β, ischemia-modified albumin (IMA), and heat shock protein 70 (HSP70) in cognitive impairment of patients with cerebral small vessel disease and to explore their clinical significance.Methods:A total of 120 patients with cerebral small vessel disease admitted to the First Hospital of Hebei Medical University from April 2020 to May 2021 were selected, including 51 males and 69 females. The patient ranged in age from 55-80 years, with an average age of (67.5±9.4) years. The patients were divided into a control group without cognitive dysfunction or a research group with cognitive dysfunction, with 60 cases in each group. The research group was divided into 3 subgroups based on imaging changes: leukoencephalopathy group (WML group), lacunar infarction group (LI group), and WML+LI group. The levels of S100β, IMA, and HSP70 in both groups were detected by enzyme-linked adsorption method, and the cognitive status of patients was assessed according to the Montreal cognitive assessment (MoCA) scale. Variables with significant differences in the analysis were used as multivariate conditions for logistic regression analysis of cognitive impairment in patients with small cerebral vascular disease.Results:Serum S100β level in the research group was higher than that in the control group, while serum IMA and HSP70, and MoCA score were all lower than those in the control group (P＜0.05 for all). Compared with the LI subgroup, the levels of S100β in the WML and WML+LI subgroups were increased, and the levels of IMA, HSP70, and MoCA score were decreased (P＜0.05 for all). Compared with the WML subgroup, the level of S100β in the WML+LI group was increased, and the levels of MA, HSP70, and MoCA score were decreased (P＜0.05 for all). Pearson correlation analysis showed that S100β was negatively correlated with IMA, HSP70, and MoCA score (r=-0.560, -0.579, and -0.635, respectively, P＜0.001 for all); IMA was positively correlated with HSP70 and MoCA score (r=0.504, 0.645, and 0.584, P＜0.001 for all); HSP70 was positively correlated with MoCA score (r=0.564, P＜0.001). Multivariate logistic regression analysis showed that serum S100β [OR (95%CI)=0.713 (0.704-0.831)], IMA [OR (95%CI)=0.744 (0.726-0.864)], and HSP70 [OR (95%CI)=0.335 (0.787-0.768)] were factors affecting cognitive impairment in patients with cerebral small blood vessel disease (P＜0.05 for all).Conclusion:With the aggravation of the disease, serum S100β level gradually increases, and serum IMA and HSP70 levels gradually decrease, which is closely related to the development of cognitive impairment in patients with small cerebral vascular disease.
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