Current status of research of pathogen infection and susceptibility-related gene polymorphisms in Kawasaki disease
Kawasaki disease is more common in younger children, mainly having systemic cardiovascular inflammatory manifestations. The etiology of Kawasaki disease remains unknown since its discovery in the 1960s and it has become the major cause of acquired heart disease in children. According to current research, the occurrence of Kawasaki disease is characterized by ethnic, regional, genetic, and genetic susceptibility. Coronary artery injury is one of the serious complications of Kawasaki disease, closely linking its occurrence to genetic polymorphisms. In recent years, the incidence of Kawasaki disease has shown an increasing trend, and the cause of which is associated with the immune response caused by infection of bacteria, viruses, Mycoplasma pneumonia, chlamydia, and other pathogens, and susceptibility-related gene polymorphisms. This paper intends to explain the research status of pathogen infection and gene polymorphisms in Kawasaki disease in recent years, in order to provide corresponding theoretical support for the treatment of patients with the disease and the follow-up study of the disease.
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