摘要
肠白塞病是白塞病累及胃肠道，以肠道溃疡性病变导致胃肠道症状为特征的白塞病特殊亚型。目前仍缺少评估疾病活动的客观工具和单一的特异性生物标志物，主要依靠内镜、活组织检查和CT扫描进行诊断、鉴别诊断、评估预后。皮质类固醇及氨基水杨酸制剂仍为一线和标准治疗方案，对皮质类固醇依赖者可联合使用免疫抑制剂或肿瘤坏死因子抑制剂。治疗过程中需要严格外科手术指征，但出现严重且危及生命的并发症，无法通过保守治疗控制时需要行外科手术治疗。本文就有关肠白塞病的诱发因素与发病机制、临床特征、常见并发症与合并症、鉴别诊断、辅助检查（实验室、肠镜和影像学）、组织病理学特征、治疗及预后予以综述，以期为临床提供一定的参考。
Abstract
Intestinal Behcet's disease is a special subtype of Behcet's disease that involves the gastrointestinal tract and is characterized by gastrointestinal symptoms caused by intestinal ulcer lesions. At present, there is still a lack of objective tools and any single specific biomarker to assess disease activity. The diagnosis, differential diagnosis, and prognosis assessment are mainly based on endoscopy, biopsy, and CT scanning. Corticosteroids and aminosalicylic acid preparations are still the first-line and standard treatment options. For corticosteroid-dependent patients, immunosuppressants or tumor necrosis factor (TNF) inhibitors (TNF-i) can be used in combination. Strict surgical indications are required during the treatment process, but when severe and life-threatening complications that cannot be controlled by conservative treatments Occur, surgical treatment is required. This article reviews the predisposing factors and pathogenesis, clinical features, common complications and comorbidities, differential diagnosis, auxiliary examinations (laboratory, colonoscopic, and imaging), histopathological features, treatment, and prognosis of Behcet's disease, with an aim to provide some reference for clinicians.
基金项目
湖北省荆门市科技计划项目(2020YDKY011)
万方数据