Relationship between serum microRNA-22 and HSPB1 levels and prognosis of patients with acute Stanford type A aortic dissection
Objective:To investigate the relationship between serum microRNA-22 (miR-22) and heat shock protein family B (small) member 1 (HSPB1) levels and the prognosis of patients with acute Stanford type A aortic dissection (ATAAD).Methods:A total of 145 patients with ATAAD admitted to our hospital from January 2020 to May 2022 (ATAAD group) were selected and divided into either a death group (22 cases) or a survival group (123 cases) according to their in-hospital survival status, and another 52 healthy individuals who underwent physical examination during the same period were selected as a control group. Clinical data of ATAAD patients were collected and serum miR-22 and HSPB1 levels were measured by qPCR and enzyme-linked immunosorbent assay. Multi-factor logistic regression was used to analyze the factors influencing death in ATAAD patients, and ROC curve analysis was performed to assess the predictive value of serum miR-22 and HSPB1 levels for death in ATAAD patients.Results:Serum miR-22 levels were lower in the ATAAD group than in the control group, and HSPB1 levels were higher than those in the control group (P＜0.05). Multifactorial logistic regression analysis showed that increased age (OR=1.077, 95% CI: 1.001 to 1.158), myocardial infarction (OR=2.963, 95% CI: 1.156 to 7.597), shock (OR=3.178, 95% CI: 1.209 to 8.359), pericardial effusion (OR=2.684, 95% CI: 1.067 to 6.751), and elevated HSPB1 (OR=1.256, 95% CI: 1.013 to 1.557) were independent risk factors for death in ATAAD patients, and elevated miR-22 (OR=0.417, 95% CI: 0.196 to 0.888) was an independent protective factor (P＜0.05). ROC curve analysis showed that the area under the curve values of serum miR-22 and HSPB1 levels alone and in combination for predicting death in ATAAD patients were 0.792, 0.782, and 0.873, respectively, with sensitivities of 81.82%, 59.09%, and 86.36% and specificities of 73.98%, 88.62%, and 76.42%, respectively.Conclusion:Decreased serum miR-22 levels and increased HSPB1 levels are independently associated with a poor prognosis in ATAAD patients and can be used as an auxiliary predictor of poor prognosis in ATAAD patients.
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