Sarcopenia is a syndrome associated with low muscle mass and muscle strength, and it is related to adverse outcomes in a variety of diseases. Sarcopenia occurs in 11% to 45% of liver cancer patients.The cause of liver cancer associated sarcopenia is the result of many factors, and the pathogenesis is still unclear. Sarcopenia has significant influence on the clinical outcome and prognosis of liver cancer. Thus, the clinical outcome and prognosis of patients with liver cancer can be improved by the intervention of sarcopenia from the aspects of nutrition, exercise, and medicine.