Correlation between neutrophil/high-density lipoprotein ratio and lower extremity arterial disease in middle-aged and elderly people
Objective:To investigate the correlation between the neutrophil/high-density lipoprotein ratio (NHR) and lower extremity atherosclerotic disease (LEAD) in middle-aged and elderly people.Methods:A total of 644 middle-aged and elderly inpatients treated at the Department of Vascular Medicine, Peking University Shougang Hospital from January 2016 to October 2017 were selected. According to brachial and ankle index, the patients were divided into either a non-LEAD group (n=578) or an LEAD group (n=66). Data collected at baseline included participants' demographic data, lifestyle, disease history, routine blood examination, and biochemistry examination. Pearson correlation analysis was used to analyze the correlation between NHR and LEAD. ROC curves were plotted to determine the predictive performance of NHR for LEAD. Multivariate Logistic regression was used to analyze the influencing factors of LEAD. One-way analysis of variance was used to compare the vascular function of different NHR groups.Results:There was no significant difference in age, sex, smoking history, drinking history, hypertension, diabetes, hyperuricemia, medication history, MON, TC, TG, AST, ALT, TBIL, DBIL, Cr, hsCRP, or HCY between the non-LEAD group and the LEAD group (P＞0.05). WBC and NEU in the LEAD group were significantly higher than those in the non-LEAD group, while LYM, LDL, and HDL in the non-LEAD group were significantly higher than those in the LEAD group (P＜0.05 or P＜0.01). Pearson correlation analysis showed that there was a negative correlation between NHR and ABI in the middle-aged and elderly population (P＜0.01). Multivariate Logistic regression showed that NHR was an independent risk factor for LEAD (P＜0.05). One-way ANOVA showed that there were significant differences in ABI, CAVI, and CF-PWV among the groups with different levels of NHR (P＜0.05). ABI in the high NHR group was smaller than that in the low NHR group, while CAVI and CF-PWV were higher in the high NHR group.Conclusion:The increase of NHR in middle-aged and elderly people is associated with LEAD, which has important value in predicting the incidence of LEAD in this population.
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