Effect of peritoneal dialysis and hemodialysis on nutritional status and inflammatory response in elderly patients with end-stage renal disease
Objective:To investigate the effect of peritoneal dialysis (PD) and hemodialysis (HD) on the nutritional status and inflammatory response in elderly patients with end-stage renal disease (ESRD).Methods:The medical records of 112 patients with ESRD in Huangshan People's Hospital from May 2019 to May 2022 were retrospectively analyzed, and they were divided into either a PD group or an HD group according to the method of dialysis used. The PD group was treated by PD, while the HD group underwent HD therapy. The renal function, inflammatory factors, immune function, nutritional status, and rate of complications before and after treatment were compared between the two groups.Results:After treatment, the blood urea nitrogen and serum creatinine levels in the both groups were lower than those before treatment (P＜0.05), but no significant difference was found between the groups (P＞0.05). The levels of procalcitonin, hypersensitive C-reactive protein, white blood cell count, and neutrophils in the PD group after treatment were lower than those of the HD group (P＜0.05). After treatment, albumin, hemoglobin, total protein, the percentages of CD4+ T cells and CD3+ T cells, and CD4+/CD8+ ratio in the PD group were higher than those of the HD group, while the percentage of CD8+ T cells was lower than that of the HD group (P＜0.05). The total incidence of complications was 14.04% in the PD group, which showed no significant difference as compared with that in the HD group (18.18%; P＞0.05).Conclusion:Compared with HD, PD has advantages in reducing the inflammatory reaction, and improving the immune function and nutritional status of elderly patients with ESRD, without increasing the risk of complications.
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