摘要
n-3多不饱和脂肪酸（n-3 PUFAs）在脑发育和包括新生儿脑损伤、孤独症谱系障碍、阿尔茨海默病、精神分裂症在内的神经系统疾病的发生发展中起到重要作用。本文综述了n-3多不饱和脂肪酸发挥脑保护作用的机制进展，包括调节突触可塑性、膜受体功能；参与信号转导途径；减轻炎症反应和产生多种脂质介质等，为找寻疾病治疗靶点并进一步进行临床转化提供理论基础。
Abstract
n-3 polyunsaturated fatty acids (PUFAs) play a variety of roles in brain development and the treatment of neurological diseases, including neonatal brain injury, autism spectrum disorder, Alzheimer's disease, schizophrenia, etc. The mechanisms underlying the protective effect of n-3 PUFAs on the brain have always been a research hotspot. The possible mechanisms include regulating synaptic plasticity and membrane receptor function, modulating signal transduction pathways, anti-inflammatory properties, and producing lipid mediators. This review reviews the progress in the understanding of the brain protective mechanisms of n-3 PUFAs, so as to help identify therapeutic targets for the relevant diseases and promote clinical translation.
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