摘要
肝素结合蛋白（HBP）是中性粒细胞受到外界刺激后释放产生的颗粒蛋白，在增加血管内皮通透性、趋化特性及调节炎症反应方面起着至关重要的作用。近年来，随着对HBP研究的逐渐深入，发现HBP可作为诊断脓毒症的早期生物标志物，并证实HBP可预测脓毒症患者疾病严重程度并判断预后情况。本文就HBP在脓毒症中的临床价值进行综述。
Abstract
Heparin-binding protein (HBP) is a kind of granule protein produced by neutrophils in response to external stimuli. It plays a crucial role in increasing vascular permeability, chemotaxis, and regulating inflammatory response In recent years, studies have found that HBP can be used as an early predictor of sepsis. In addition, it has been confirmed that HBP can be used to evaluate the disease severity and prognosis in sepsis patients. This review focuses on the clinical value of HBP in sepsis.
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