摘要
靶控输注（TCI）是一种静脉输注药物以达到特定体室或组织预设浓度（靶浓度）的给药技术。医学大数据时代的到来，TCI技术日趋成熟，一方面，为实现现代麻醉的智能化，自动给药系统的开发研究逐渐得到重视；另一方面，TCI药代模型的优化则强调了麻醉的个体化。本文就现代医学背景下TCI多通道闭环系统与药代模型优化的研究进展进行综述，为探究TCI的发展趋势提供参考。
Abstract
Target controlled infusion (TCI) is a technique of infusing intravenous drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. TCI is becoming widely used with the advent of big data in medicine. In order to realize the intellectualization of modern anesthesia, more attention has been paid to the development and research of automatic drug delivery systems, while the optimization of TCI models emphasizes the individualization of anesthesia. This review intends to link TCI to modern medicine and thus to illustrate the multichannel closed-loop system and the optimization of pharmacokinetic models, which will characterize the future development of TCI.
万方数据