Progress in research of pharmacokinetic models for intelligent target controlled infusion
Target controlled infusion (TCI) is a technique of infusing intravenous drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. TCI is becoming widely used with the advent of big data in medicine. In order to realize the intellectualization of modern anesthesia, more attention has been paid to the development and research of automatic drug delivery systems, while the optimization of TCI models emphasizes the individualization of anesthesia. This review intends to link TCI to modern medicine and thus to illustrate the multichannel closed-loop system and the optimization of pharmacokinetic models, which will characterize the future development of TCI.
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