Progress in understanding of role of MUC16/CA125 in diagnosis and treatment of benign and malignant tumors
MUC16/CA125 is a kind of glycoprotein tumor marker that can originate from mesothelial cells, Miller duct epithelium in benign tissue, and their derivatives in malignant diseases. MUC16/CA125 has different roles in benign and malignant tumors. On the one hand, it participates in the occurrence and development of malignant tumors through signaling pathways such as MUC16-siglec-9, MUC16-galectin-1/3, MUC16-mesothelin, MUC16-selectin, and MUC16-JAK2. On the other hand, it mainly has the functions of local buffering, lubrication, anti-inflammation, and maintaining homeostasis in non-malignant tumors. In this paper, we discuss the identification of diseases related to elevated serum CA125 and its role in the diagnosis and treatment of benign and malignant tumors. Further research is needed to explore MUC16/CA125 as a new specific tumor marker and target for new drugs.
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