Hydrogen for treatment of myocardial ischemia-reperfusion injury: mechanism and prospect
Myocardial ischemia-reperfusion injury (MIRI) is one of the key causes of myocardial injury, secondary to cardiovascular diseases, which is mostly present in coronary heart disease and during the perioperative period of cardiac surgery. MIRI elicits oxidative stress, inflammatory activity, and cell apoptosis, with a high incidence and mortality rate. The current treatments for MIRI include medicines and physical therapy, but with unsatisfactory effects. As a small molecule non-toxic reducing gas, hydrogen has a clear protective effect against cell ischemia-reperfusion, and has therefore become a promising treatment for MIRI. This paper reviews the mechanism of hydrogen for the treatment of MIRI and the preliminary prospect of its clinical application in the future.
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