摘要
代谢相关脂肪性肝病（MAFLD）是一种严重威胁公众健康的疾病，其发病机制尚不清楚。肠道微生物群及其代谢产物对MAFLD的发展有重要影响。在这篇综述中，笔者主要强调肠道微生物群及其代谢产物影响MAFLD的关键机制，并阐述了通过益生菌、益生元、合生元和粪菌移植（FMT）调节肠道微生物群来治疗MAFLD的研究。
Abstract
Metabolic-associated fatty liver disease (MAFLD) is a serious public health threat and its pathogenesis is still not completely clear. Studies have shown that the intestinal microbiota and its metabolites have an important role in the development of MAFLD. In this review, we focus on the key mechanisms by which the intestinal microbiota and its metabolites influence MAFLD. In addition, we also discuss the treatment of MAFLD by modulating the intestinal microbiota through probiotics, prebiotics, synbiotics, and fecal microbiota transplantation.
基金项目
海南省临床医学中心建设项目资助(2021818)
海南省院士团队创新中心建设项目资助(2022136)
海南省院士创新平台科研项目资金资助(YSPTZX202313)
海南省卫生健康行业科研项目资助(22A200078)
海南省研究生创新科研课题(Qhyb2022-133)
海南医学院研究生创新科研课题(HYYB2022A18)
万方数据