目的:探讨中学生的血尿酸与血清25（OH）D3水平的关系，旨在为高尿酸血症的防治提供更多的理论依据。方法:选择石景山区217名中学生采用尿酸酶过氧化物酶法测定其血尿酸水平，采用电化学发光法测定其血清25（OH）D3水平。同时测量2组患者的血压、身高、腰围、体重，计算BMI，并通过调查问卷了解其饮食习惯、运动、睡眠情况等。并进一步针对研究对象男女分布进行了性别亚组分析。2组间计量资料比较采用2组独立样本 t 检验。通过Pearson相关分析男生血尿酸水平及其与血清25（OH）D3的关系。通过校正多因素的二元Logistic回归分析法，评估男生的血清25（OH）D3水平、饮食习惯、运动、睡眠等与高尿酸患病率的危险程度，采用二元 Logistic 回归分析计算血 25（OH）D3 每升高一个单位，高尿酸血症的患病比值比（OR）及其 95% 可信区间（CI）。结果:217名学生中高尿酸比例37.33%（81/217），高尿酸组中BMI、腰围、收缩压、舒张压均大于正常组差异具有统计学意义（P＜0.05）。男生高尿酸组中25（OH）D3（19.01±6.48）低于正常组（21.81±6.31），差异具有统计学意义（P＜0.05）；男生血尿酸水平与25（OH）D3呈负相关，r=-0.22，P=0.032；通过校正运动、饮料、睡眠、茶等多因素后，25（OH）D3是尿酸的独立保护因素（OR=0.933，P=0.045）。结论:该研究证实血25（OH）D3与高尿酸血症呈负相关，且该相关性仅在男生中成立。
Association between serum uric acid and serum 25(OH)D3 levels in middle school students in Shijingshan District, Beijing
Objective:To observe the changes of serum uric acid and serum 25(OH)D3 levels in middle school students, and to explore their relationship.Methods:A total of 217 middle school students in Shijingshan District, Beijing were selected to measure their serum uric acid levels by uricase peroxidase method, and their serum 25(OH)D3 levels by electrochemiluminescence method. Meanwhile, blood pressure, height, waist circumference, and weight were measured, and body mass index was calculated. Furthermore, subgroup analysis by gender was carried out. The measurement data between the two groups were compared by two independent samples t test. The relationship of the levels of serum uric acid in boys with serum 25(OH)D3 was analyzed by Pearson correlation. Multivariate binary logistic regression analysis was performed to evaluate the association of serum 25(OH)D3 level, eating habits, exercise, sleep, etc. with the prevalence of hyperuricacidemia in boys. For each unit increase in 25(OH)D3, the odds ratio (OR) of the prevalence of hyperuricemia and its 95% confidence interval (CI) were calculated.Results:Among the 217 students included, the proportion of students with high uric acid was 37.33% (81/217), and their diastolic blood pressure was significantly higher than that of students with normal uric acid (P＜0.05). The 25(OH)D3 level (19.01±6.48) in boys of the high uric acid group was significantly lower than that in the normal uric acid group (21.81±6.31; P=0.041); the serum uric acid levels of boys were negatively correlated with 25(OH)D3 levels (r=-0.22, P=0.032). After adjusting for beverage, sleep, tea, and other factors, 25(OH)D3 was an independent protective factor for high uric acid (OR=0.933, P=0.045).Conclusion:This cross-sectional study confirmed that blood 25(OH)D3 is inversely correlated with hyperuricemia, and such correlation only exists in boys.
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