首页|细胞蜡块技术在甲状腺细针穿刺病理诊断中的价值研究

细胞蜡块技术在甲状腺细针穿刺病理诊断中的价值研究

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目的:探讨甲状腺细针穿刺细胞蜡块技术对提高病理诊断准确性的意义。方法:随机选择河北省人民医院113例术前可疑且术后病理证实为甲状腺乳头状癌患者,手术前行细针穿刺后并进行了常规细胞学涂片和制作细胞蜡块。两种技术方法制作的涂片/切片进行满意度评价,评价两种方法的在病理诊断中的准确性。结果:细胞蜡块法制作切片细胞排列结构完整,细胞核和细胞质结构清晰,不受红细胞影响,不满意度为0.9%(1/113),常规涂片组不满意度为8.8%(10/113),差异有统计学意义(P<0.05)。甲状腺乳头状癌诊断正确率方面,细胞蜡块法阳性率(110/113,97.3%)比常规涂片法阳性率(100/113,88.5%)高,差异有统计学意义(P<0.05)。结论:对比甲状腺穿刺常规细胞涂片,细胞蜡块的满意度更高、诊断正确率更高;此外细胞蜡块还可以做免疫组织化学染色,解决疑难诊断问题。
Value of cell block technique in pathological diagnosis of papillary thyroid carcinoma by fine needle aspiration
Objective:To explore the value of cell block technique in thyroid fine needle aspiration to improve the accuracy of pathological diagnosis of thyroid diseases.Methods:One hundred and thirteen cases of papillary thyroid carcinoma from Hebei General Hospital were randomly selected, and routine cytological smears and cell embedding were performed after fine-needle aspiration. The diagnostic results were confirmed by postoperative pathological results.Results:There was a statistically significant difference in the degree of dissatisfaction between the cell block group (1/113, 0.9%) and the conventional smear group (10/113, 8.8%). In terms of the diagnostic accuracy for papillary thyroid carcinoma, the positive rate in the cell block group (110/113, 97.3%) was significantly higher than that of the conventional smear group (100/113, 88.5%; P<0.05).Conclusion:Compared with conventional cell smear, cell block technique has a higher degree of satisfaction and higher diagnostic accuracy. In addition, cell blocks can also be immunohistochemically stained to solve difficult diagnostic problems.

杜倩、张曼、李丽、马晓丽

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050000 石家庄,河北省人民医院病理科

050000 石家庄,河北省人民医院手术室

050000 石家庄,河北省人民医院超声科

细胞蜡块 细胞涂片 细针穿刺 甲状腺乳头状癌

河北省卫健委青年科技课题

20190403

2023

中华临床医师杂志(电子版)
中华医学会

中华临床医师杂志(电子版)

CSTPCD
影响因子:0.99
ISSN:1674-0785
年,卷(期):2023.17(10)
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