Progress in the association between triglyceride-glucose index and microvascular complications in type 2 diabetes
Triglyceride-glucose index (TyG) is a new measure of assessing insulin resistance (IR), reflecting glycolipid toxicity. Blood glucose, triglyceride (TG), and IR lead to diabetic microangiopathy through mechanisms including enhancing oxidative stress, damaging blood vessels, and weakening vasodilatation. TyG and diabetic microvascular complications, most studies showed a positive association of TyG with diabetic peripheral neuropathy (DPN), diabetic kidneg disease (DKD), diabetic retinopathy (DR), diabetic foot (DF) and diabetic foot ulcer (DFU) risk, some studies showed that TyG is not related or negatively associated with the above complications. At present, the mechanism and correlation of TyG and the microvascular complications of type 2 diabetes are reviewed in order to explore the role of TyG in the diabetic microvascular complications and provide risk factors for the prevention and treatment of microvascular complications.
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