摘要
甘油三酯-葡萄糖指数（TyG）是评估胰岛素抵抗（IR）的新指标，反映糖脂毒性。血糖、甘油三酯（TG）、IR通过增强氧化应激、损伤血管、减弱血管舒张功能等机制导致糖尿病微血管病。TyG与糖尿病微血管并发症相关性不一致，大部分研究显示TyG与糖尿病周围神经病变（DPN）、糖尿病肾病（DKD）、糖尿病视网膜病变（DR）、糖尿病足（DF）及糖尿病足溃疡（DFU）患病风险呈正相关，部分研究显示TyG与上述并发症不相关或负相关。目前就TyG与2型糖尿病微血管并发症的机制、相关性做一综述，以期探究TyG在糖尿病微血管并发症中的作用，为防治微血管并发症提供危险因素。
Abstract
Triglyceride-glucose index (TyG) is a new measure of assessing insulin resistance (IR), reflecting glycolipid toxicity. Blood glucose, triglyceride (TG), and IR lead to diabetic microangiopathy through mechanisms including enhancing oxidative stress, damaging blood vessels, and weakening vasodilatation. TyG and diabetic microvascular complications, most studies showed a positive association of TyG with diabetic peripheral neuropathy (DPN), diabetic kidneg disease (DKD), diabetic retinopathy (DR), diabetic foot (DF) and diabetic foot ulcer (DFU) risk, some studies showed that TyG is not related or negatively associated with the above complications. At present, the mechanism and correlation of TyG and the microvascular complications of type 2 diabetes are reviewed in order to explore the role of TyG in the diabetic microvascular complications and provide risk factors for the prevention and treatment of microvascular complications.
基金项目
2020年云南省高层次人才培养万人计划“名医”专项(YNWR-MY-2020-008)
2018年云南省卫生健康委医学学科头人(内分泌学)培养计划项目(D-2018034)
2022年云南省内分泌与代谢性疾病临床医学中心(临床重点学科)分中心建设项目()
万方数据