摘要
microRNA-107（miR-107）是具有多种疾病中起调节作用的miRNAs，在肿瘤细胞的生长、分化、增殖、发育、凋亡和代谢等多种过程中发挥重要作用，与多种肿瘤有关。在恶性肿瘤的发生发展中，有时作为癌基因促进恶性肿瘤的进展，有时又作为抑癌基因对恶性肿瘤起到抑制作用。总之，miR-107极有可能成为恶性肿瘤的诊断和治疗中新的生物标志物。本文对miR-107在不同系统恶性肿瘤中的作用及其可能机制进行具体阐述，并对其今后的研究方向提出自己的见解，旨在为miR-107在恶性肿瘤的诊治方面起到一定的推动作用。
Abstract
MicroRNA-107 (miR-107) is a microRNA that plays a regulatory role in various diseases. It plays an important role in various processes such as tumor cell growth, differentiation, proliferation, development, apoptosis, and metabolism, and is associated with various tumors. In the occurrence and development of malignant tumors, miR-107 may act as an oncogene to promote the progression of malignant tumors, and it can also act as a tumor suppressor gene to suppress malignant tumors. Thus, miR-107 is highly likely to become a new biomarker in the diagnosis and treatment of malignant tumors. This article provides a detailed explanation of the role and possible mechanisms of miR-107 in malignant tumors of different systems, and proposes our own insights into the future research directions, aiming to promote the diagnosis and treatment of malignant tumors.
基金项目
湖北省中医药管理局2023-2024年度项目(ZY2023F032)
万方数据