Progress in understanding of relationship between ceramide and cardiovascular disease
Cardiovascular disease (CVD) is a major category of diseases threatening human health and life. Ceramide is a simple bioactive sphingolipid that plays a role in the pathogenesis of diabetes and CVD. Ceramide has been shown to accumulate in many tissues of individuals with CVD, including the vascular system and the heart. In recent years, more and more studies have shown that ceramide is closely related to a variety of CVDs. Ceramide is involved in the occurrence and development of CVD, and has predictive value especially for hypertension, coronary atherosclerotic heart disease, and heart failure. Future studies are needed to confirm whether reducing ceramide levels and the reactive enzymes involved in ceramide synthesis pathways can reduce the severity and risk of serious outcomes in CVD.
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